Villains that act as an overarching antagonist of their work. It's possible for a TUE character to be both a big bad and a bigger bad if they are the big bad in one work and the bigger bad in another one.
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A
D
- Damballa
- Dark One
- Darkrai (Pokémon Mystery Dungeon)
- Darkseid (DC Animated Movie Universe)
- Darkseid (DC Animated Universe)
- Darkseid (DC Extended Universe)
- David Jehoahaz Abraham
- Davoth
- Death (Netflix's Castlevania)
- Deathborn
- Diz
- Don Eladio
- Dr. Arthur Gallup
- Dr. Emilia
- Dr. James Sheridan
- Dr. Roosevelt
- Dr. Weil
- Dr. Wily (Mega Man X)
E
G
K
M
S
T
- Tathamet
- Thanos (Marvel's Guardians of the Galaxy)
- The Archivists
- The Black Mass
- The Chroma
- The Darkness (Skylanders)
- The End
- The Entity (Burdens of a Timeline Traveler)
- The Entity (Mr. Hopp's Playhouse)
- The Fallen (Transformers Original Films)
- The General (Hotline Miami)
- The Nothing (Fortnite)
- The Overlord
- The Van
- TIO
- Trigon (Teen Titans 2003)
- Trundle
U